William Scoresby, Jr., an Arctic explorer, scientist, and Anglican minister, surveyed the scene from a small boat ferrying him and his brother-in-law from Corkbeg Island to the town of Cobh, just across the harbor. It was, at first glance, an utterly normal day at the docks. Brawny longshoremen heaved crates to and fro with casual ease, chattering gulls swooped through the briny air, and a motley collection of vessels mingled amid rippling waters. 46), with 32.6% of participants in each arm maintaining HbA1c of 6.0% or less at 2 years.Īlthough initial induction IIT induces metabolic improvement, subsequent repeat courses of IIT every 3 months do not further enhance the effect of MET maintenance therapy on beta-cell function.īeta-cell function induction intensive insulin therapy intermittent insulin maintenance preservation.The morning of June 26, 1828, dawned bright and full of promise over southern Ireland’s Cork Harbor.
Baseline-adjusted HbA1c at 2 years did not differ between MET and MET + IIT (6.3% ± 0.1% vs. The primary outcome of baseline-adjusted ISSI-2 at 2 years was not improved by the addition of intermittent IIT (MET + IIT) and was slightly higher in the MET arm (baseline-adjusted difference -35 ), with three additional beta-cell measures showing no significant differences. In both arms, induction IIT increased ISSI-2, improved whole-body insulin sensitivity and reduced hepatic insulin resistance (all P ≤. Beta-cell function was assessed by the Insulin Secretion Sensitivity Index-2 (ISSI-2) at an oral glucose tolerance test every 3 months. In this multicentre, randomized controlled trial, 108 adults with type 2 diabetes (median 1.3 years' duration HbA1c 6.6% ± 0.6%) were randomized to 3 weeks of induction IIT (glargine, lispro) followed by MET maintenance, either with or without periodic 2-week courses of IIT every 3 months for 2 years. To test the hypothesis that the addition of periodic courses of short-term intensive insulin therapy (IIT) could enhance the effect of metformin (MET) maintenance therapy on preservation of beta-cell function following induction IIT.
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